Gene

itcha

ID

ZDB-GENE-120919-4

Name

itchy E3 ubiquitin protein ligase a

Symbol

itcha Nomenclature History

Previous Names

itch

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have ubiquitin protein ligase activity. Predicted to be involved in positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to localize to cytoplasm. Is expressed in posterior lateral line primordium. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Angers et al., 2014

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Angers et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With itcha Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Autoimmune disease, multisystem, with facial dysmorphism	613385

Associated With itcha Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR000569	HECT domain
Domain	IPR001202	WW domain
Family	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
Family	IPR050409	E3 ubiquitin-protein ligase
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036020	WW domain superfamily